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Formulation and Evaluation of Gastroretentive Mucoadhesive Tablet of Gliclazide by using Synthetic Polymers

Singh Vikas* and Pallavi Joshi

Gliclazide is an oral anti hyperglycemic agent used to treat non-insulin dependent diabetes mellitus. Aim of the present work is to formulate and evaluate mucoadhesive tablet of Gliclazide by using synthetic polymers like HPMC K4M, and carbopol 940. The tablets were formulated by direct compression method and then evaluated pre-compression and post compression such as hardness, friability, thickness, weight variation, drug content, drug release, FTIR, mucoadhesive strength. Polymers and drug have no interactions in IR. The formulation was found to have good pre-formulation characteristics. Formulation (F3) showed good mucoadhesive strength (22.720 g) and maximum drug release of 57.4% in 10 hours. The drug content has shown 96.56%. All the evaluation parameters given the positive result and comply with the standards. Advantage of mucoadhesive tablet is increase the residence time and control the release of drug as well as enhance bioavailability. It also improves patient compliance, drug efficacy, and therapeutic effects.

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