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Abstract

Evaluation of Anti-oxidant and Wound Healing Property of Anogeissus acuminata Leaves

Mohd Amer AK, Iqbal MM*, Rehman MAU, Asadulla SB and Jat RK

Plants are the “sleeping giant of drugs development”. They form a reservoir of potential useful untapped sources of drugs that have been serving mankind since dawn of civilization. Hence it is necessary to explore the possibility of using the traditional medicines with proper chemical and pharmacological profiles.

Wound healing is a complex and dynamic process involving the phases of haemostasis, inflammation, granulation and maturation. Thermal injury is one of the most severe forms of trauma that affects the organism both locally and systematically. Localized burns affect the skin and hermits ability to act both as a protective barrier to the environment and as an immune organ. Burn wound healing is a complex process consisting of an early phase of abrupt energy depletion and necrosis, followed by inflammatory phase, delayed cell death, formation of granulation tissue, matrix formation and remodelling.

In the present study the systemic evaluation procedure is followed for determining any possible excision, burn wound healing and antioxidant activities of Anogeissus acuminate leaves were carried out. Alcoholic and aqueous extracts of Anogeissus acuminate leaves possessed maximum antimicrobial activity. The LD50 of both the extracts were found to be 3000 mg/kg b.w (p.o.).

The wound healing studies of alcoholic and aqueous extracts showed significant wound healing activity and anti-oxidant property at 300 mg/ kg dose as compared to control. From the dead space wound studies, it was found that alcoholic and aqueous extracts of Anogeissus acuminata significantly increased the tensile strength of granuloma and there was significant increase in the weight of cotton pellet granuloma than the control. Wound healing activity and histopathological studies of the leaves of Anogeissus acuminata on excision wound model, incision wound model, formation of granuloma, collagen contents in the tissues were significant when compared to control.


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