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Authors Huda Kafeel, Ramsha Rukh, Asma Zubair, Ayesha Ghazala, Hira Muzaffar, Hira Raees, Kanwal Riaz, Tania Qudsia, Zunaira Ali
Description The main objective of this study is to investigate the prevalence of functional secondary amenorrhea and also to study the different variable factors associated with it with its possible pathological outcome in our community. A retrospective study is conducted in the city of Karachi. Data regarding the occurrence of amenorrhea, specifically functional secondary amenorrhea, their related complications and symptoms were collected together with demographic variables by means of structured questionnaire. Study sample was of 1052 women (age between 13 to 48 years) out of 1258 women approached. (n= 1052 with response rate 83.62%) 12 women out of 1052 (1.14%) gave a history of primary amenorrhea with no onset of menstrual cycle even at the age of 15. Contrary there were 44.77% women having history of no onset of menstrual cycle for more than 3 months duration during the past year. (Secondary amenorrhea).  5.04% was due to established ovarian cause like PCOs and 39.73% was due to functional causes like stress, excessive dieting, exercise or use of medications (like oral contraceptives or sedative hypnotics or SSRI’s) classified as Functional secondary amenorrhea. 11.12% amenorrhea was due to pregnancy. Among different variables studied weight, age, marital status, pregnancy history was found to be significant. A significant correlation between the use of oral contraceptives and secondary amenorrhea was found in about 7.03% of women. Obesity was found to be the most common effect in women having secondary amenorrhea.