VITAMIN E POTENTIATE THE ANTIEPILEPTIC ACTIVITY OF PHENOBARBITAL

N.P. Sawadadkar*, V.S. Ughade, V.S. Shinde, P.N. Kothari, A.A. Shinde, V.J. Chaware, K.R. Biyani

Phenobarbital is the mostly used drug for the seizures. However question regarding safety and efficacy of this drug make it particularly compelling to identify adjunct therapy that could boost therapeutic benefit. Study found that one adjunct therapy is vitamin e. The main aim of present study was to evaluate potentiation of anticonvulsant activity of Phenobarbital by vitamin e in mice using PTZ induced convulsions. In these methods all the animals were divided into sixteen groups & each groups consist of six animals. All group received PTZ. Testing drugs doses were randomised within groups of animal such that each group was required during a given test series. The results revealed that vitamin e significantly potentiated efficacy of phenobarbital but did not exert antiepileptic effect on its own. Concurrent administration of phenobarbital and vitamin e also decreased serum MDA activity. It is concluded that vitamin e potentiates the antiepileptic activity of phenobarbital.