Bhawna Khurana, Ritesh Bajaj, Lohit Girotra
Liposomal drug delivery can be put forth as the cynosure for the release kinetics of lipophillic drugs that require compartmental models in its therapeutics and triggers. The localization of the drug at the site of action, rate of achieving the therapeutic index and Circulation lifetime are the key parameters for a liposome. Lately, their arises a need for a multi-compartment structure consisting of drug-loaded liposomes encapsulated within another bilayer, is a promising drug carrier with better retention and stability. A vesosome contemplates a large lipid bilayer enclosing many smaller liposomes, serving as a support for the customization of separate environments for multiple therapeutics and release triggers, highlighting the vesosomes potential as a single site, single dose, and multiple component drug treatment. The permeation rate, membrane charge, specific recognition particles, steric stabilizers, membrane rigidity, and phase transition temperatures all play a role in optimization of vesicles for particular delivery applications. The vesosomes are optimized on the basis of phase behavior exhibited by homogeneous lipid mixtures. A variety of microscopy techniques, including freeze-fracture and cryo-transmission electron microscopy as well as fluorescence and confocal microscopy are used for characterization of these lipophillic, eukaryotic cell like species. The present paper tries to tap another vesicular drug delivery comport such that release and bioavailability of liposomes is taken to another level.
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