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Abstract

VALIDATION OF A UV-SPECTROPHOTOMETRIC METHOD FOR THE ASSAY AND PURITY OF PARACETAMOL IN SOLUTIONS FOR IV INFUSION, AND COMPARISON OF MARKETED BRANDS

*Tabbouche O. S, Soukkariyyeh I, Naji M and Alwan T

Paracetamol or chemically named p-acetyl-N-aminophenol is a unique analgesic and antipyretic widely used in the hospital setting all over the globe. The Paracetamol solution for IV infusion is clinically the standard analgesic in Pain Management and the first line, most safe antipyretic especially in the Pediatrics Department. According to many pharmacopoeias, the UV spectroscopy is still one of the most validated and relied on quality control assays in pharmaceutical research. Our research objective is to compare the purity and quantity of the Active Pharmaceutical Ingredient (API) “Paracetamol” in five different brands of Paracetamol solution for IV infusion present in the Lebanese market. The ?max was 244nm in all five brands which confirms purity of the API, however Amax was the highest in Bofalgan (Bosch Pharma) and lowest in Perfumol (Hikma Pharmaceuticals). The highest concentration was observed in Perfalgan (Bristol Myers Squibb), while the lowest concentration was observed in Perfumol (Hikma Pharmaceuticals).


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Citations : 938

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