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Validated Spectrophotometric method for estimation of Paclitaxel in Bulk and Pharmaceutical Formulation

Indrayani D. Raut*1, Rajendra C. Doijad 2, Shrinivas K.Mohite1

A simple, precise, rapid UV method has been developed for the determination of Paclitaxel in bulk and its pharmaceutical dosage form. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. Paclitaxel is used to treat patients with lung, ovarian, breast, head and neck cancer, and advanced forms of Kaposi's sarcoma. Various methods for analysis of same are available but are time consuming and expensive. Here we have developed new, precise, simple spectrophotometric method for estimation of Paclitaxel from bulk. Medium prepared were selected phosphate buffer PH 10. It showed absorption maxima at 230 nm.This method were validated according to ICH guidelines. The drug obeyed Beers law and showed good correlation. The linearity was observed between 5-55 μg/mL . There was no significant difference in the intraday and interday analysis of Paclitaxel determined. The results of analysis were validated with respect to recovery, linearity; Limit of detection and limit of quantitation were found to be satisfactory.

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