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Validated Analytical Method Developed for Estimation of Ondansetron by Spectroscopy in Pharmaceutical Dosage Form

Sehgal Tanya*, Praveen K and Meenu C

The present research was undertaken to develop a spectroscopic method for determination of Ondansetron in pharmaceutical dosage forms. This paper describes a simple, rapid, accurate and precise UV-spectroscopic method for the assay of Ondansetron in bulk and marketed tablet dosage forms. The method is based on UV spectroscopic technique. Ondansetron shows the maximum absorbance at 302 nm in absorption maxima method. Drug followed the linearity in the range of 4-24 μg/ml for this method with correlation coefficient (r2) of 0.999. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The method was validated as per the International Conference on Harmonization (ICH) guidelines. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and sensitive.

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