V. Bindu Praneeta*, B. Sukanya Bai, V. Usha Vanya, M. Mahima Swaroopa
Narcolepsy is a chronic neurological disorder specifying the abnormal sleep manifestations which mainly impact the quality of life of narcolepsy patients. The exact cause is unclear but found significant evidences that orexin/hypocretin deficiency causes narcolepsy which regulates sleep. Treatment focuses on symptomatic relief throughout medication, education, and behavioral therapy. Stimulants are the first line treatment for the excessive daytime sleepiness. Modafinil, sodium oxybate, amphetamine, methylphenidate, and selegiline are effectual treatments for somnolence associated with narcolepsy. Tricyclic antidepressants and SSRIs are one of the best treatments for cataplexy, sleep paralysis, and hypnagogic hallucinations. Benzodiazepines are the best regimen for disturbed nocturnal sleep.
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