Toxicological Studies of an Ayurvedic Medicine �??Swalpo Chandrodoy Makardhwaj�?� Used as Geriatric Rejuvenator

Massnoon Ali, Md. Mamun Sikder, Uday Krishna Mondal, Konica Arju Leeza, Manoth Kumer Biswas, Md. Rakib Hasan, Runa Masuma, and M. S. K. Choudhuri*

Swalpo Chandrodoy Makardhwaj (SCM) is an Ayurvedic geriatric rejuvenator used as a traditional medicine in the rural area of Bangladesh. To find out the toxicological characteristic of SCM, it was administered chronically to the male Sprague-Dawley rats at a dose of 100 mg/kg for 32 days and the following toxicological changes were noted. All throughout the experimental period the SCM treated animals were always maintaining negligible changes in body weight. There is a statistically significant (p=0.012) decrease in the organ water content of the male rat lungs whereas a statistically significant (p=0.044) increase was noted in case of organ water content of liver. There is a statistically significant increase in relative percent weight of rat kidney (p=0.028) and absolute weight of rat spleen (p=0.024). There is also a statistically significant (p=0.034) increase in the relative percent weight of the male rat spleen.