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Abstract

Toxicological Studies of an Ayurvedic Medicine ???Swalpo Chandrodoy Makardhwaj??? Used as Geriatric Rejuvenator

Massnoon Ali, Md. Mamun Sikder, Uday Krishna Mondal, Konica Arju Leeza, Manoth Kumer Biswas, Md. Rakib Hasan, Runa Masuma, and M. S. K. Choudhuri*

Swalpo Chandrodoy Makardhwaj (SCM) is an Ayurvedic geriatric rejuvenator used as a traditional medicine in the rural area of Bangladesh. To find out the toxicological characteristic of SCM, it was administered chronically to the male Sprague-Dawley rats at a dose of 100 mg/kg for 32 days and the following toxicological changes were noted. All throughout the experimental period the SCM treated animals were always maintaining negligible changes in body weight. There is a statistically significant (p=0.012) decrease in the organ water content of the male rat lungs whereas a statistically significant (p=0.044) increase was noted in case of organ water content of liver. There is a statistically significant increase in relative percent weight of rat kidney (p=0.028) and absolute weight of rat spleen (p=0.024). There is also a statistically significant (p=0.034) increase in the relative percent weight of the male rat spleen.


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