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Abstract

TOXICOLOGICAL STUDIES OF AN AYURVEDIC MEDICINE KANKAYANA GUTIKA

Tanmony Sana1, Md. Mamun Sikder1, Paritosh Chakma1, Marjana Khalil2, Nayma Abedin1, Md. Al Foyjul Islam1, Mohammad Jashim Uddin3 and M. S. K. Choudhuri1*

Kankayana Gutika (KKY) have been used for the treatment of gulma (localized abdominal swelling or tumor) in Indian subcontinent. However, safety and efficacy of this treatment have not been evaluated. Therefore, the present study was carried out to evaluate the efficacy and safety of KKY in experimental animals. During this study, various experiments on body growth rate, organ-body weight ratio and tissue hydration indices were performed to evaluate its efficacy and toxicity. To find out the toxicological characteristic of KKY, it was administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/kg for 46 days and the following toxicological changes were noted. All throughout the experimental period the KKY treated animals were always maintaining negligible changes in body weight. There is a statistically very highly significant (p=0.001, 25.4% decrease) decrease in the relative percent weight of the male rat liver. There is also a statistically significant (p=0.026, 35.80% decrease) decrease in the relative percent weight of the male rat thymus.


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