Abstract
SYNTHESIS OF SOME D-GLUCOSE LINKED 1,2,3-TRIAZOLES AS UREASE INHIBITORS
Zeyad Kadhem oleiwi*, Ezzat Hussein Zimam
This research include synthesis of some new 1,2,3-triazole from D-glucose .The synthesis was started by preparation of phenyl propargyl ether derivative from the reaction of phenol with propargyl bromide . The second step of synthesis was performed by the click reaction of glycosyl azide of protected glucose with acetylenic ether to form 1,2,3-triazole derivatives. The biological activity of synthesized compounds were tested against urease activity. Some of these compounds (T1, T2,Tr3) show high inhibition action on the enzyme activity , while (T4)do not show any effect on the activity .
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