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Abstract

SYNTHESIS OF 9-BROMO-N-SUBSTITUTED- 6H- INDOLO [2, 3-b] QUINOXALINE-3-SULFONAMIDE DERIVATIVES CONTAINING QUINOXALINE MOIETY AS PROSPECTIVE ANTIMICROBIAL AGENTS

Sandeep Talari*1, Govindarajan R2, Divya Karunakaram3, Srikanth Jupudi2 and Udhayavani S2

O-phenylene diamine is reacted with 5-bromo Isatin and the resultant compound is reacted with various aromatic and aliphatic amines to form the 9-bromo-N-substituted- 6H- indolo [2,3-b] quinoxaline-3-sulfonamide derivatives of Quinoxaline (QXN 1 to QXN 12). All the compounds were structurally elucidated with physical and analytical methods. All the compounds were evaluated with anti-microbial activity against a variety of bacterial strains (both Gram +ve and Gram –ve) and fungal strains and some of these compounds have shown significant antibacterial and antifungal activities.


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