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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF NOVEL ISATIN SUBSTITUTED IMIDAZOLINE DERIVATIVES

T. Maneshwar, N.Vijetha, V.Balakrishna, Ch.Vijay Kumar, M.Suresh

Novel Isatin substituted Imidazole derivatives have been synthesized and screened for anthelmintic activity. Literature revealed that vast majority of Isatin and imidazole compounds are known to possess pharmacologically proven therapeutic potentials. Isatine substituted 5-Oxo-imidazoline derivatives were synthesized from 1,3-oxazole5-ones which were synthesized from the benzoyl glycine by Erlynmayer synthesis. These 5-oxazoline compounds upon condensation with isatine semicarbazide, it formed isatine substituted 5-oxo-imidazoline derivatives (3a-3j). All compounds have been characterised using IR, 1H NMR and Mass spectral data and have been evaluated for their antmelmintic activity and Albendazole was used as a standard drug.


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