SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME NEW COUMARIN DERIVATIVES OF PHARMACEUTICAL INTEREST

B. Susmitha, P.V. Naveen, G.Jhansi, G.Chaitanya, B. Anupama, KNV Chenchulakshmi*

A series of new coumarin derivatives were prepared by condensation of resorcinol and ethyl aceto acetate followed by sulfonation with chlorosulphonic acid and amination with various water soluble primary amines .The synthesised compounds were characterised by physical properties and spectral studies (IR,1HNMR,13CNMR). The compounds were evaluated for antibacterial activity against both gram positive and gram negative organisms with standard benzyl penicillin.