SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PYRIMIDINE DERIVATIVES

Ayushi Uniyal*, Alka N. Choudhary, Preeti Kothiyal

A series of 3-amino-4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione derivatives have been synthesized by cyclization of substituted chalcones with thiosemicarbazide. The structures of all newly synthesized compounds were confirmed by FT- IR, 1H NMR and Mass spectral analysis. The synthesized compounds were screened for antibacterial activity (500μg/ml) concentration level by disc diffusion method against (Gram negative) Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia.