Karishma Yogeshkumar Halatwala*, Devarshi Shah, R. K. Parikh
Sublingual dosage form is to be placed under the tongue and produce immediate systemic effect by enabling the drug absorbed directly through mucosal lining of the mouth beneath the tongue which is very reach to vascular blood supply. Here the sublingual spray is to be sprayed for faster onset of action. The absorption of drug through sublingual route is 3-10 times greater than that given oral route. Main advantages include elimination of first pass effect, rapid drug absorption, high efficacy, large surface area, drug stability, ease of termination of therapy and many more. Drug directly go to the arterial circulation by sublingual vein and capillaries and then to jugular vein and then to the Superior vena cava. Pharmaceutical preparations for sublingual administration are manufactured in the forms of: tablets, drops, film, and sprays. Therefore current write up is focused on anatomical structure of sublingual route, its blood supply, mechanism of drug absorption, advantages and disadvantages of sublingual spray with their marketed formulation has been discussed.
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