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Stabity indicating Dissolution Method Development for Estimation of Paracetamol & Chlorzoxazone in Combine Dosage form

H.N khan1*, M D Zameeruddin2, Mirza Shahed Baig2, Mahajan Swarali2, V.B Bharkad2

The present work concerns with development and validation of dissolution test for Paracetamol and Chlorzoxazone in combine tablets dosage form using spectrophotometric method. 0.1M HCl (pH 1.0, 900 mL) was used as dissolution medium, using a paddle apparatus, stirring rate was 50 rpm. The percent drug release was determined by UV spectrophotometric method the wavelength selected for analysis are 242.80 nm for Paracetamol and 279.80 nm for Chlorzoxazone from results it can be concluded that the method developed consists in an efficient alternative for assay of this tablets combination. The method was validated to meet requirements for a global regulatory filing which includes validation parameters as linearity, accuracy, precision, ruggedness and robustness which are as per ICH guidelines. In addition, filter suitability and drug stability in medium were demonstrated. 

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