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Abstract

STABILITY STUDIES OF THE OPTIMIZED ORAL CONTROLLED RELEASE VERAPAMIL HYDROCHLORIDE TABLET FORMULATIONS

Ahmad Khan*, Jallat Khan, Hafiz Shoaib Sarwar, Kamran Hidayatullah, Amina Riaz, Zanib Chaudhry

In the present study accelerated testing (6 month) and long term testing (12 month) were carried out on Oral Verapamil Hydrochloride control release tablet in order to assess the physical and chemical stability of Verapamil Hydrochloride tablets. All the formulations were tested for disintegration test, % drug content and % drug release over the entire period of testing. These formulations did not show any significant change in any parameter during 12 month and 6 month of testing at 25+5??C/60+5% RH and at 40+2??C/75+5% RH, respectively. All the results were within the acceptable limits. Shelf lives calculated by software R Gui were found to be 43.452, 43.577 and 43.234 months at 1, 3 and 6 months for F4 in accelerated stability. However shelf lives were 44.112, 41.634, 41.867 and 42.896 months at 1, 3, 6 and 12 months respectively in long term stability.


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