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Abstract

SIMULTANEOUS HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF OXICAMS IN PHARMACEUTICAL FORMULATIONS

Wael Abu Dayyih, Ahmad Abu Hamaid, Kamal Swiedan, Khalid Matalka, Eyad Abu Nameh

A highly sensitive, accurate and rapid HPLC analytical method for the determination of Tenoxicam (TEN), Piroxicam (PIR) and Meloxicam (MEL) in a finished dosage form was developed and validated. C18 reversed phase column was used. The mobile phase was composed of methanol and aqueous buffer solution (disodium hydrogen phosphate dihydrate mixed with citric acid) (60:40),at pH of 5.8. The flow rate was 1.2 ml/min and the applied analytical wavelength was 360 nm. The calibration curve was linear over the range 1.010- 3.030, 1.513-4.538 and 1.765-5.295 mg/L for TEN, PIR and MEL, respectively. The lower limit of detection and the lower limit of quantification for TEN were 0.06 and 0.18 mg/L, while they were 0.09 and 0.28 mg/L, for PIR, and 0.12 and 0.38 mg/L, respectively for MEL. The peaks resolution was tested under several conditions and found that 5% increase of organic mixture or a 0.5 increase in the pH buffer would decrease the peak resolution between PIR and MEL. In conclusion, such method may successfully replace the classical analytical methods of Oxicams.


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