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Abstract

SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND TELMISARTAN IN TABLET DOSAGE FORM BY LIQUID CHROMATOGRAPHY

Vineetha Vykuntum, Gajja Vijaykumar and Kudipudi Harinadha baba

A simple, rapid and accurate reverse phase-high performance liquid chromatographic method for the simultaneous determination of Atorvastatin and Telmisartan in tablet dosage form is developed and validated. The chromatographic analysis was performed on a kromasil C18 column (150×4.6 mm, 3.5 μm) in isocratic mode, the mobile phase consisted of acetonitrile and phosphate buffer (adjusted to pH 3.8 with ortho-phosphoric acid) at a ratio of 70:30 v/v, and a flow rate of 1.0 mL/min. The eluents were monitored at 278 nm. The retention time of Atorvastatin and Telmisartan were found to be 2.804 min and 3.875 min, respectively. The linear ranges were found to be 50-90 μg/mL (r2=0.9992) for Atorvastatin and 12.5-22.5 μg/mL (r2=0.999) for Telmisartan. The proposed method is also found to be accurate, precise and robust. The method could be applied to routine quality control of pharmaceutical formulations containing Atorvastatin and Telmisartan.


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Citations : 938

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