GET THE APP

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ANTIHYPERTENSIVE DRUGS OLMESARTAN AND CILNIDIPINE IN BULK AND TABLET DOSAGE FORM

P. Harshalatha*, K.B.Chandrasekhar and M.V.Chandrasekhar

A new reversed-phase HPLC method was developed and subsequently validated for simultaneous estimation of antihypertensive drugs Olmesartan and cilnidipine in pharmaceutical dosage forms. Chromatography was carried out on Inertsil C-18 column (4.6 x 150mm, 5μ particle size) with a mobile phase composed of buffer and acetonitrile in 55:45%v/v and the mobile phase was pumped at a flow rate of 1.0 mL/min. Detection was carried out using a PDA detector at 225nm. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness were studied as reported in the International Conference on Harmonization guidelines. The retention times for olmesartan and cilnidipine were 2.2 min and 3.7 min respectively. The linearity range for olmesartan and cilnidipine were 10-60 μg/mL and 5-30 μg/mL. The percentage recoveries of olmesartan and cilnidipine were 98.01% and 98.88%, respectively. This method can be employed for routine quality control of olmesartan and cilnidipine tablets in quality control laboratories and pharmaceutical industries.


PDF
scan code pharma scholars

Manuscript Submission

Submit your manuscript at  Online Submission System


Google scholar citation report
Citations : 1101

International Journal of Pharmacy received 1101 citations as per google scholar report

International Journal of Pharmacy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • HINARI
  • Index Copernicus
  • Google Scholar
  • The Global Impact Factor (GIF)
  • Polish Scholarly Bibliography (PBN)
  • Cosmos IF
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • EBSCO A-Z
  • OCLC- WorldCat
  • MIAR
  • International committee of medical journals editors (ICMJE)
  • Scientific Indexing Services (SIS)
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Eurasian Scientific Journal Index
  • Root indexing
  • International Institute of Organized Research
  • InfoBase Index
  • International Innovative Journal Impact Factor
  • J-Gate