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Abstract

PREPARATION AND EVALUATION OF SOLID DISPERSIONS OF NIMESULIDE

Swathi Gunturu and Divya Amaravadi

Nimesulide is a non-steroidal anti-inflammatory drug. Here, the present study was planned to prepare and evaluate the solid dispersions of Nimesulide. Solid dispersions of Nimesulide were prepared by using various hydrophilic carriers like PVP K-40, PEG 4000, PEG-6000 in various ratios by solvent evaporation method. The solubility of Nimesulide in different solvents; water, acetone and ethanol was enhanced in the form of solid dispersions. The prepared solid dispersions were subjected to solubility studies (in water, 0.1 N HCL and phosphate buffer pH 7.4. Stability studies were carried out at 40±2° C and at 75±5 % RH. The phosphate buffer pH 7 Showed highest solubility for the drug. The cumulative amount of drug release of Nimesulide: PVP K-40 was 97.06 %; Nimesulide: PEG-4000 was 97.42%; Nimesulide: PEG -6000 was 97.46% respectively. Therefore it can be concluded that dissolution rate of poorly soluble drug (Nimesulide) can be significantly enhanced by formulating them into solid dispersions


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