PRELIMINARY EVALUATION OF BAUHINIA RACEMOSA LAM CAESALPINACEAE SEED MUCILAGE AS TABLET BINDER

Gangurde AB and Boraste SS

The objective of present investigation was to evaluate Bauhinia racemosa Lam. Caesalpinaceae seed mucilage as a binder for pharmaceutical dosage forms. Natural mucilages are economic, easily available and found useful as tablet binder. No work has been reported on it as a tablet binder. Granules were prepared with its varying concentrations and evaluated for tablet characteristics. Wet granulation technique was used for the preparation of amoxicillin trihydrate granules. The binder concentrations used in the formulation were 2, 4, 6 & 8 % w/w. The evaluation of granules showed 0.52 to 0.72 mm granule size, 28 to 31 º angles of repose and 20.53 to 11.81 % fines. The evaluation of tablets showed 3.52-0.89% w/w friability, 4 to 12 min disintegration time and more than 90% dissolution in 60 min. Tablets at 8% w/w binder concentration showed more optimum results as tablet binder. The mucilage was found to be useful for the preparation of uncoated tablet dosage form.