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Abstract

PRECLINICAL BLOOD CHEMISTRY SAFETY PROFILE STUDIES OF NARADIYA LAKSMIVILASA RASA ON THE KIDNEY FUNCTION AFTER CHRONIC ADMINISTRATION TO MALE SPRAGUE-DAWLEY RATS

S. J. Sarah Muneem1, Tania Nasrin2, Md. Rakib Hasan1, Nayma Abedin1, Swagata Sarker Lopa1,Kamrun Nahar3, Faria Farzana Perveen4and M. S. K. Choudhuri1*

Naradiya Laksmivilasa Rasa (NMB) is a classical Ayurvedic formulation, indicated for the treatment of sinusitis, chronic skin diseases, diabetes, obesity, rheumatoid arthritis, headache, gynaecological disorders and urinary tract infections. However, till date, no safety profile of this formulation has been reported. That is why, the present study was conducted to evaluate the effect of conventionally prepared NMB on different kidney profile parameters in experimental animals. Acute toxicity study was conducted to determine the median lethal dose (LD50) of the drug. The LD50 study of NMB recorded no death or any signs of toxicity even at the highest dose of 4000 mg/Kg body weight. To find out the effect of chronic administration of NMB on serum kidney profile, it was administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/kg for 43 days. Naradiya Laksmivilasa Rasa significantly decreased albumin and A/G ratio and significantly increased globulin, urea and Blood Urea Nitrogen (BUN) level. BUN/Creatinine and Urea/Creatinine level were significantly increased in NMB treated rats when compared to normal control. The drug (NMB) did not affect total protein and creatinine level significantly. This experimental data will help the clinician for the logical use of NMB in different disease conditions. 


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