ORGAN BODY WEIGHT RATIO TOXICITY STUDIES OF AN AYURVEDIC MEDICINE CHINTAMANICHATURMUKH RAS USED IN VERTIGO

Tasniya Nahiyan Zulfiquar, Md. Mamun Sikder, Tanmoy Sana, Imtiaj Hossain Chowdhury, Nilay Saha, Sagor Chandra Roy, Runa Masuma and M. S. K. Choudhuri*

Chintamanichaturmukh Ras (CMC) is an Ayurvedic preparation used as a traditional medicine in the treatment of vertigo in the rural population. To find out the toxicological characteristic of CMC, it was administered chronically to the male Sprague-Dawley rats at a dose of 40 mg/kg for 28 days. After 28 days chronic administration of the CMC preparation, the following toxicological changes were noted. All throughout the experimental period the CMC treated animals were always maintaining decrease in body weight but it was not significant. There was a statistically significant (p=0.039; 9.28 % decrease) decrease in the relative percent weight of the male rat heart. There was a statistically significant decrease in the absolute weight of the male rat liver (p=0.018; 19.04 % decrease) and a statistically highly significant decrease was noted in case of relative percent weight of the liver (p=0.01; 18.61 % decrease). There was also a statistically highly significant (p=0.002; 4.31 % decrease) decrease in the organ water content of the rat liver.