GET THE APP

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

NORDIHYDROGUAIARETIC ACID: DUAL BEHAVIOR AS PRO- OR ANTIOXIDANT ON A EUKARYOTIC CELL MODEL (VERO CELLS).

Brenda S. Konigheim, Juan J. Aguilar, Laura B. Tauro, María E. Rivarola, Marta S. Contigiani, Susana C. Nuñez-Montoya*

Since Nordihydroguaiaretic acid (NDGA), a potent natural antioxidant, can produce oxidation in several cell kinds, mainly by superoxide anion production (O2·¯), the current study was designed to assess its capacity to produce or not this reactive oxygen species on Vero cell line, with the aim to establish whether this lignan behaves as a pro- or antioxidant. The O2·¯ production was determined by the Nitro Blue Tetrazolium reduction test. Results show that NDGA has a dual-face behavior on this eukaryotic cell model depending on the biological environment and its concentration. The NDGA behaved as a pro-oxidant when it was tested single, by means of an increase in O2·¯ production that was directly concentration-dependent. Mixed with an antioxidant (ascorbic acid) or a moderate oxidant (glucose), the NDGA behaved as pro-oxidant at low concentrations and antioxidant at high concentrations.


PDF
scan code pharma scholars

Manuscript Submission

Submit your manuscript at  Online Submission System


International Journal of Pharmacy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • HINARI
  • Google Scholar
  • The Global Impact Factor (GIF)
  • Polish Scholarly Bibliography (PBN)
  • Cosmos IF
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • EBSCO A-Z
  • International committee of medical journals editors (ICMJE)
  • Scientific Indexing Services (SIS)
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Eurasian Scientific Journal Index
  • Root indexing
  • International Institute of Organized Research
  • InfoBase Index
  • International Innovative Journal Impact Factor