MINIMUM INHIBITORY CONCENTRATION AND MINIMUM BACTERICIDAL CONCENTRATION OF AZITHROMYCIN TABLET IN BANGLADESH

Suharto Chakma and M. Amirul Islam

The azithromycin tablet in Bangladesh maintains standard MIC and MBC. But how much is this assumption is true; this will be evaluated through this research work. This is a cross sectional study to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of selected azithromycin tablet. The collected samples were analyzed according to USP specification. The MICs of azithromycin were determined by broth dilution method. MBCs were determined by the drop plate method from the tubes, where apparently no visible growth found. This study showed that MIC & MBC values of azithromycin tablet found highest against Pseudomonas spp., Shigella spp. and E. coli were > 64.0 mg/ml (micro gram per milliliter) and lowest against B. pumillus was 1.0/2.0 mg/ml. MIC and MBC values higher than that of the peak serum concentration of azithromycin must have chance of therapeutic failure and development of azithromycin tolerance and resistance to the bacteria tested. To evaluate the efficiency of antibiotic there are two factors2. Which influence potential utility of a antibiotics in a specific clinical situation. The first is the measure of potency of the antibiotic for the pathogen in question minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The second is relationship between the concentration time profile and potency of the antibiotics. This research work will play an important role to determine the MIC and MBC of selected azithromycin tablet in Bangladesh