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Abstract

METHOD DEVELOPMENT AND VALIDATION OF ATAZANAVIR SULFATE BY VARIOUS ANALYTICAL TECHNIQUES - A REVIEW

C. Divya*, A. Ajitha, T. Rama Mohana Reddy, V. Umamaheswara Rao

Atazanavir Sulfate is a sulfate salt form of atazanavir, an aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl)hydrazine moiety with activity against both wild type and mutant forms of HIV protease. Atazanavir does not elevate serum lipids, a common problem with other protease inhibitors. In this review, we discussed various analytical methods like UV, HPLC, LC-MS for the estimation of Atazanavir Sulfate in pharmaceutical dosage forms.


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Citations : 938

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