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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF MONTELUKAST AND LEVOCETIRIZINE IN PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

K. Venila Rani*, H. Padmalatha

A simple, Accurate, precise method was developed for the simultaneous estimation of the Montelukast and Levocetirizine in liquid dosage form. Chromatogram was run through Hypersil BDS 250 x 4.6 mm, 5µ. Mobile phase containing Buffer and Acetonitrie in the ratio of 35:65A was pumped through column at a flow rate of 1ml/min. Buffer used in this method was 0.02M Potassium di-hydrogen phosphate buffer at pH 3.6. Temperature was maintained at 30°C. Optimized wavelength for Montelukast and Levocetirizine was 231nm. Retention time of Montelukast and Levocetirizine were found to be 2.599min and 3.472min %RSD of the Montelukast and Levocetirizine were and found to be 0.7 and 0.8, respectively. % recovery was obtained as 99.88% and 99.9%for Montelukast and Levocetirizine respectively. Regression equation of Montelukast is y = 35120x + 388.3 and Levocetirizine is y = 29047x + 721.3.


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