LIQUISOLID COMPCT: A NOVEL APPROCH TO ENHANCE BIOAVAILABILITY OF POORLY SOLUBLE DRUG

Sandip Vajir

Liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles. In this case, even though the drug is in a solid dosage form, it is held within the powder substratein solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Large scale production of fabricated drug on commercial level.succesful liquisolid tablet is a determination of optimal flowable liquid retention.