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Abstract

IN-VITRO AND IN-VIVO CORRELATION OF IMMEDIATE RELEASE ACYCLOVIR TABLET USING WAGNER NELSON METHOD

Somnath Sakore and Bhaswat Chakraborthy

The purpose of this study was to establish In-Vitro and In-Vivo correlation of immediate release Acyclovir tablets of 800 mg. In vitro and in vivo studies are done on the test product as Acyclovir Tablet USP 800 mg (containing Acyclovir 800 mg) of Cadila Pharmaceuticals Ltd., India versus Zovirax® Tablet 800 mg (containing Acyclovir 800 mg) of GlaxoSmithKline, USA. In vivo studies are done in 36 healthy, adult, human subjects under fasting condition.In vitro dissolution study was done using USP apparatus II at 50 rpm in 0.1N HCL for 45 minutes. The in vitro–in vivo correlation of Acyclovir shows R-squared value 0.9794 in excel work sheet, which depicts a successful correlation between in vitro and in vivo Characteristic of the drug. In addition, %PE AUC and %PE Cmax was found to be –4.604 and -11.19 respectively for each formulation. The present study shows a good correlation between in vivo and in vitro PK profiles of the formulation used as the test drug in the study.


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Citations : 938

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