INFLUENCE OF XANTHUM, GUAR AND ACACIA GUM ON RELEASE OF EXTENDED RELEASE TABLET OF TRAZADONE HYDROCHLORIDE

*Vaishali S. Kadam and G. R. Shendarkar

The objective of this work was to formulate extended release tablets of highly water-soluble Trazadone Hydrochloride using natural gums xanthum, guar and acacia gum as cost effective, nontoxic, easily available and suitable hydrophilic matrix systems by direct compression method and to study the effect of different concentration of polymers like xanthum gun, guar gum, and acacia on release rate from tablet. FTIR analysis does not show any interaction of drug with Excipients. Formulation was optimized on the basis of acceptable pre and post compressional parameters. The results of dissolution studies indicated that Batch F6 exhibited drug release of 93% at the end of 12h to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from Batch F6 formulation was sustained up to 12 h. Fitting in-vitro drug release data from optimized matrix formulation to zero order followed by Higuchi model indicated that diffusion could be mechanism of drug release. The n value indicates a non-fickian or anomalous diffusion pattern. This means that both the diffusion and erosion mechanisms were prevalent.