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Abstract

INFLUENCE OF SUPER DISINTEGRATING AGENTS ON IN-VITRO RELEASE OF CHLORPHENIRAMINE MALEATE SUBLINGUAL TABLETS

*Reddy Sunil, Goli. Vinitha, Yasmeen Tabassum, A. Venkatesham

The term Sublingual referred as “under the tongue”. In this route of administration the drug permeates through the tissues under tongue into the blood stream. The Sublingual route of administration play important role in avoiding first pass metabolism. The main objective is to improve bioavailability, rapid onset of action and solubility of the drug increased and protein binding is avoided. Sublingual tablets of Chlorpheniramine maleate formulated by using direct compression method. Nine formulations were formulated using Rotary compression machine to explain the effects of the sodium starch glycolate, Cross Povidone, Cross Carmellose Sodium on disintegration time, In-vitro release of the drug and % drug release. In addition the tablets are also evaluated for the weight variation, thickness, diameter, hardness, wetting time, water absorbivity ratio, FTIR, DSC and drug release studies. The Batch F8 is having the higher dissolution and disintegration rate for optimized sublingual Chlorpheniramine maleate tablet, for rapid onset of action for management of tussiveness. The F8 Formulation is having less wetting time and high water absorption ratio. 


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