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N. Waman, R. Ajage, P. N. Kendre, S.B.Kasture, Veena Kasture*

Metaxalone is BCS class II drug having low solubility and high permeability. The solubility and bioavailability of poorly soluble drug was increased by designing microemulsion based drug delivery system of Metaxalone for oral drug administration. The microemulsion was prepared using Tween 80, PEG-400 as surfactant and cosurfactant, sesame and castor oil and water .The formulation was evaluated for globule size, viscosity, RI, pH, conductance, % transmittance and % drug content. The in-vitro intestinal drug diffusion was carried using Frantz diffusion cell and in-vivo drug activity was measured by using animal model. The microemulsions were transparent; particle size was in the range of 45.39 - 271 nm. The viscosity lies between 88 and 95.5cps, pH was found to be 8.12 - 8.17. The Formulated microemulsion had better drug permeation as compared to the pure drug and its marketed dosage form, had good muscle relaxant activity in mice. Study concluded that Metaxalone in microemulsion form exhibited increased solubility and improved drug release.

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