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Ghanshyam Panigrahi, Uma Shankar Mishra, Sujata Mahapatra, Chhayakanta Panda, Gourishyam Pasa and Deepak Ku Hati

The aim of this study has been to investigate the possible hypoglycemic and hypolipidemic effect of methanolic extract of the plant Glinus oppositifolius. The methanolic extract of Glinus oppositifolius was tested for antihyperglycemic activity in glucose overloaded hyperglycemic rats and hypoglycemic activity in overnight fasted normal rats. The extract was also evaluated for antihyperlipidemic activity in triton-induced hyperlipidemic rats. All the methods were carried out at three dose levels, 100, 200 and 400 mg/kg respectively. The results of the study were expressed as mean ± SEM, n=6 and data was analyzed by using one way analysis of variance test (ANOVA) followed by Bonferroni's Multiple Comparison Test with 5% level of significance (P<0.05). The methanolic extract of Glinus oppositifolius exhibited significant antihyperglycemic activity (P<0.05) at 200 and 400 mg/ kg but did not produce hypoglycemia in fasted normal rats. It also exhibited a significant reduction (P<0.05) in serum lipid profile like total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase in high density lipoprotein (HDL) in hyperlipidemic rats as compared to hyperlipidemic control statistically. All the activities were found dose dependent. This study supports the traditional claim and the methanolic extract of this plant possessed significant hypoglycemic and hypolipidemic effect could be added in traditional preparations for the ailment of complications associated with hyperglycemic and hyperlipidemic conditions or as an adjuvant with existing therapy.

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