HEPATOPROTECTIVE ACTIVITY OF MUSA SAPIENTUM FRUIT PEEL (MSPE) AGAINST STREPTOZOTOCIN ??? INDUCED TOXICITY IN RATS

S. Sathiya Narayana Murthy*, Christilda Felicia Jebakani, S. Sundara Pandian, S. Ponmozhi

In this study, to assess the Hepatoprotective activity of Acetone extract of Musa sapientum fruit peel (MSPE) against Streptozotocin (STZ) induced hepatotoxicity in rats. Totally Thirty six male albino wistar rats were divided in to 6 groups; Group I received distilled water; animals in the Groups II,III,IV,V are induced single injections STZ 45mg/kg intraperitonialy; Groups IV,V,VI received MSPE in doses of 200,400,800 mg/kg/day respectively. The result obtained in this work was determined the MSPE at the doses 200 and 400 mg/kg/day showed significant hepatoprotective effect by reducing the serum marker enzymes such as Serum Alanine aminotransferase (ALT), Aspartate amino transferase (AST) and Alkaline phosphatase(ALP) and its Histopathological studies further confirmed the hepato protective of MSPE when compared with the STZ induced hepatotoxicity groups. In the conclusions present study findings of Acetone extract of Musa sapientum fruit peel showed significant hepatoprotective activity compared with control groups.