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Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF CYCLOBENZAPRINE HCl PELLETS FOR EXTENDED RELEASE

Sarada Anepu*, Balasubrahmanyam A.V.S, Lohithasu Duppala, Anu Pravallika.J

The aim of the present study is to formulate and evaluate the cyclobenzaprine hydrochloride extended release pellets by using commercially available sugar pellets by powder layer (using fluidized bed coater) process using different polymers like ethyl cellulose N-50, hydroxyl propyl methyl cellulose (HPMC), and eudragit E-100. FTIR studies of the F6 formulation indicating no chemical interaction between cyclobenzaprine HCl and excipients. In order to get the optimized formulation, the various process parameters were adjusted. The various evaluations for formulations were carried out, that to based on the in-vitro drug release studies of F6 formulation shows better drug release profile than other formulations. The results conclude that trial F6 has met the objective of extended release, cost effective as once day of drug.


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