Hand sanitizer gel products that use alcohol as an active ingredient are considered to be less safe for health because alcohol is an organic solvent that can dissolve the layer of fat and sebum on the skin which functions as a protector against infection with microorganisms. If the concentration of gelling agent carbopol is too high, a new gel will be formed at pH sour one. Sweet orange peel contains antibacterial compounds that are used as active substances in hand sanitizer gel preparations to replace alcohol. Carbopol and HPMC were combined with the aim of covering the shortcomings of carbopol to obtain gel preparations with better physical properties. There are 3 formulas with a combination of gelling agent concentrations, namely FI (Carbopol: HPMC 0.75%: 0.25%), FII (Carbopol: HPMC 0.5%: 0.5%), FIII (Carbopol: HPMC 0.25%: 0.75%). The preparations were tested for physical properties including organoleptic, homogeneity, irritation, pH, dispersibility and stability tests and then the data were analyzed using SPSS. The best formulation that meets the criteria for physical properties and physical stability of the gel preparation. The results showed that the combination of Carbopol and HPMC had an effect on the physical properties of the gel preparation, namely pH, dispersibility, and physical stability of freeze thaw and had no effect on organoleptic, homogeneity and irritation. Formula 3 with a combination of Carbopol: HPMC (0.25%: 0.75%) was chosen as the best and most stable formula, it was seen from the dispersion and pH of the preparation that met the criteria for the best and most stable gel in the freeze thaw test.
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