Swaroopa Arvapalli*, D. Swapna, MD Faizal, K. Rajashekar, J.V.C. Sharma
The purpose of present investigation was to develop and evaluate gastroretentive drug delivery system of fluoroquinolone antibiotics (Balofloxacin). These floating tablets were prepared with the objective to obtain site-specific drug delivery and to extend its duration of action. More over the non effervescent system of balofloxacin will provide increased local and systemic action in stomach. Floating non-effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose HPMC (K 15M, E50), Xanthum gum, Guar gum, Carbopol 976P, polypropylene foam powder were used. All the formulations were evaluated for floating properties, swelling characteristics and drug release studies. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow zero order release and super case 2 transport diffusion mechanism. The floating lag time were found to be significantly increased with the increasing concentration of the polymers. After the dissolution study of prepared balofloxacin non-effervescent floating tablet was concluded that the formulation NF9 with HPMC K15 and carbopol 976P show best controlled release effect (98.24%). The release kinetic data implies that the release mechanism of all the formulations was Zero order kinetics and super case 2 transport mechanism. The developed floating tablets of balofloxacin may be used to prolong drug release for at least 12h, thereby improving the bioavaibility and patient compliance.
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