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Formulation and Evaluation of Sildenafil Citrate Nanosuspension

M. Sreenivasulu Reddy, A. Jayaraju, M. Rafiyuddin and J. Sreeramulu*

In the present study, an attempt was made to prepare oral Nanosuspension of Sildenafil citrate is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension. Nano suspension containing the drug were prepared by precipitation method using combinations of polymers (such as PVP K-25, Sodium lauryl sulphate (SLS), TWEEN-80, poloxamer (188), and methanol). Estimation of Sildenafil citrate was carried out spectrophotometrically at 293nm. The Oral Nanosuspension were evaluated for various physical and biological parameters, drug content uniformity, particle size analysis, zeta potential, in-vitro drug release, short-term stability, drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F1 to F9 (containing PVP K-25, TWEEN-80, SLS, Poloxamer (188), and Methanol) used different ratio were found to be promising, of that formulation F3 containing PVP-K25 showed 99.85% release at the end of 20min & it follows zero order drug release kinetics. These formulations have displayed good Nanosuspension strength.

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