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Abstract

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF ZAFIRLUKAST

T. Lakshm Prasanna*1, Dr. P. Jayachandra Reddy2. Dr. K. Umasankar3, K. Jyosthana Devi4, I.Rajitha

Pulsatile delivery system is capable of delivering drug when and where it required most.Time delayed tablets,designed to release drug after apredictable lagtime, are intended for oral chronotherapy.The basic design consists of a core tablets prepared by direct compression method. The tablets were coated with an inner swellable layer containing sodium alginate & ethyl cellulose.The prepared pulsatile tablets were evaluated for the drug content,thickness and in-vitro release profile, etc. In-vitro releaseprofile sofpulsatile device during six hours studies were found to have very good sustaining efficacy. During the first five hour sit shows minimum drug release and at the end of six hours immediate release was observed. Increasing the level of the rupturable layer increased mechanical strength and retarded the water uptake and thus prolonged the lagtime. Stability studies proved that coating of tablets seems to decrease the effect of temperature and moisture on the degradation of Zafirlukast. The programmable pulsatile release has been achieved from table to vera 7-8 hr period, consistent with the demands of chrono therapeutic drug delivery.


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