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Abstract

FORMULATION AND EVALUATION OF HERBAL TABLET CONTAINING METHANOLIC EXTRACT OF CALOPHYLLUM INOPHYLLUM

Uma Shankar Mishra, Murthy PN, Sudhir Kumar Sahoo and Kanhu Charana Sahu

The present paper deals with formulation and evaluation of herbal tablets prepared from methanol extract of the selected plant. A solid pharmaceutical dosage formulation using a novel dry plant extract (stem barks) using various excipients viz., sprays dried lactose, starch 1500, and Aerosil-200 and magnesium stearate by direct compression method. The absorption curve of Calophyllum inophyllum Methanolic extract showed characteristic absorption maximum at 278 nm in 0.1N HCl. The drug obeyed Beer’s law in the concentration range of 10mcg/ml to 180mcg/ml, and it was found to be linear with r2 = 0.999, regression equation Y = 0.013x + 0.005. It was found that the release rate of drug increased as the percentage of starch 1500 was increased from 10 mg to 30mg. As the concentration of starch 1500 increased the release rate increased from 67.49% to 99.35% (CIT4) in 6 hours by increasing the concentration of starch 1500. The optimized formulation CIT4 of the drug was subjected to accelerated stability studies and the results were reproducible, even on tablets that had been stored for about 3 months at 250C/60% RH, 300C/60% RH and 400C/75% RH.


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