GET THE APP

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

FORMULATION AND EVALUATION OF CORDIA DICHOTOMA FRUIT MUCILAGE AS MATRIX FORMING AGENT FOR SUSTAINED RELEASE OF PROPRANOLOL HYDROCHLORIDE

D. Lohithasu*, A.V.S. Madhu Latha, D. Midhun Kumar and P. Girish

The objective of the present study was to design sustained release tablets of Propranolol HCl by direct compression using HPMC K 100 M and Cordia dichotoma fruit mucilage. Tablets were prepared by direct compression method and prepared tablets were subjected to physicochemical studies, in vitro drug release kinetic studies and stability studies. FTIR studies were shown that, there was no interaction between drug and polymer. The physicochemical properties of tablets were found within the limits. The optimized formulation (F6) was subjected to stability studies for three months at 40 ??C, RH 75 ± 5 % and showed there were no significant changes in drug content, physicochemical parameters and release pattern. The kinetic treatment of selected formulation (F6) showed that the release of drug follows Higuchi models. The obtained results of the present study indicated that Cordia dichotoma fruit mucilage as matrix former in sustained release formulation of Propranolol HCl.


PDF

Manuscript Submission

Submit your manuscript at  https://www.scholarscentral.org/submissions/international-pharmacy.html


Google scholar citation report
Citations : 938

International Journal of Pharmacy received 938 citations as per google scholar report

International Journal of Pharmacy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • HINARI
  • Google Scholar
  • The Global Impact Factor (GIF)
  • Polish Scholarly Bibliography (PBN)
  • Cosmos IF
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • EBSCO A-Z
  • International committee of medical journals editors (ICMJE)
  • Scientific Indexing Services (SIS)
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Eurasian Scientific Journal Index
  • Root indexing
  • International Institute of Organized Research
  • InfoBase Index
  • International Innovative Journal Impact Factor