EVALUATION OF TOTAL FLAVONOLS, TOTAL PROANTHOCYANIDINS CONTENT AND THROMBOLYTIC ACTIVITY OF METHANOL EXTRACTS OF THREE BANGLADESHI PLANTS

Mohammad Shah Hafez Kabir, Mohammad Abdul Hakim Murad, Abul Hasanat*, Md. Abdul Hamid, Md. Imtiaze Islam, , Tanvir Ahmad Chowdhury, Mahmudul Hasan, Mohammed Munawar Hossain, Md. Abdullah Al Masum, Mohammed Rakib Uddin

Premna esculenta (Roxb.), Crotalaria pallida (Aiton.) and Euphorbia neriifolia (Linn.) are three Bangladeshi plants, which examined for determination of proanthocyanidins, flavonols content and thrombolytic activity of methanol extracts. Crotalaria pallida showed highest content of flavonols (82.45±0.44 mg Quercetin/g) and proanthocyanidins (120.97±1.02 mg Catechin/g). It also showed highest clot lysis effect, which was 41.81±4.12%. Premna esculenta and Euphorbia neriifolia exhibit 17.27±1.57% and 34.57±1.99% compared with standard Streptokinase 75±0.09% clot lysis. They both showed well flavonols content, but proanthocyanidins content of Euphorbia neriifolia (17.86±0.26 mg Catechin/g) is less, where Premna esculenta had 106.62±1.29 mg Catechin/g.