EVALUATION OF IN VITRO MEMBRANE STABILIZING ACTIVITY AND THROMBOLYTIC ACTIVITY OF AVERRHOA BILIMBI LEAF EXTRACTS

Mohammad Mooneem Mannan, Rumana Akhter, Mohammad Shahriar* and Mohiuddin Ahmed Bhuiyan

Averrhoa bilimbi L. belonging to the family Oxalidiaceae has local name include belembuis an important multipurpose tropical tree under-recognized for its nutritional medicinal properties. In this present study, the leaf extracts of A. bilimbi were subjected to a comparative evaluation of the membrane stabilization and thrombolytic activity. The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte and the results were compared with standard streptokinase (SK) and standard anti-inflammatory drug, acetyl salicylic acid (ASA) respectively. The crude chloroform extract of the leaves of A. bilimbi demonstrated better membrane stabilizing activity, whereas its methanol and ethanol soluble fractions revealed moderate membrane stabilizing properties compared with standard. The crude extracts were found to have thrombolytic activity with a maximum effect in ethanolic fraction comparable with streptokinase as a positive control and water as a negative control.