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Abstract

EVALUATION OF ANTIOXIDANT AND ANTIHYPERLIPIDEMIC POTENTIAL OF SIDA CORDIFOLIA LINN. IN EXPERIMENTAL ANIMALS

Mehul V. Makwan, Nilesh M. Pandya2, Bhavik D. Doshi, Dharmesh N. Darji, Sarav A. Desai and Bhaskar VH

The present study was aimed to evaluate antioxidant and antihyperlipidemic activity of an aqueous extract of root of Sida cordifolia Linn. (SCAE) against Triton WR-1339 and High fat diet (HFD) induced hyperlipidemia in experimental animal. Effect of simultaneous administration of SCAE in different doses (200 & 400 mg/kg) by oral route was estimated in Triton WR-1339 and HFD induced hyperlipidemic animals by estimating serum lipid levels of cholesterol (TC), Triglycerides (TG), Low density lipoproteins (LDL), High density lipoprotein (HDL) and Very low density lipoprotein (VLDL) and atherogenic index. Whereas antioxidant activity was carried out by estimating serum levels oxidative marker Superoxide dismutase (SOD) and Catalase (CAT). From the study, it was revealed that the aqueous extract of Sida cordifolia possesses significant hyperlipidemic activity in acute as well as chronic hyperlipidemic models in the company of promising antioxidant activity. So, it was concluded that aqueous extract of Sida cordifolia possesses potential antioxidant and antihyperlipidemic activity in experimental animals.


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