EVALUATION OF ANTINOCICEPTIVE AND ANTIOXIDANT PROPERTIES OF THE ETHANOLIC EXTRACT OF SIDA CORDIFOLIA ROOT FROM BANGLADESH

Hemayet Hossain, Md. Sariful Islam Howlader, Shubhra Kanti Dey, Arpona Hira, Arif Ahmed

The crude ethanolic extract of the roots of Sida cordifolia Linn. (Family: Malvaceae) was evaluated for its possible antinociceptive and antioxidant properties growing in southeast part of Bangladesh. The ethanolic extract of roots of Sida cordifolia exhibited statistically significant (p>0.001) writhing inhibition in acetic acid induced writhing model in white albino mice (Swiss-webstar strain). The crude extract produced 25.77% inhibition of writhing at the dose of 250 mg/kg body weight & 44.11 % inhibition of writhing at the dose of 500 mg/kg body weight while the standard drug diclofenac inhibition was found to 51.97 % at a dose of 25 mg/kg body weight. The antioxidant property of ethanolic extract of Sida cordifolia was assessed by DPPH (1, 1-diphenyl-2-picryl hydrazyl) free radical scavenging activity. In DPPH scavenging assay the IC50 value was found to be (65 μg/ml) which was comparable to the standard ascorbic acid (16 μg/ml). Phytochemical nature (group determination of plant constituent) and selected phytochemical analysis of the ethanolic extract of the roots of Sida cordifolia indicated the presence of steroid, reducing sugars, tannin & saponin types of compounds. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.