Hemayet Hossain, Md. Sariful Islam Howlader, Shubhra Kanti Dey, Arpona Hira, Arif Ahmed
The crude ethanolic extract of the roots of Sida cordifolia Linn. (Family: Malvaceae) was evaluated for its possible antinociceptive and antioxidant properties growing in southeast part of Bangladesh. The ethanolic extract of roots of Sida cordifolia exhibited statistically significant (p>0.001) writhing inhibition in acetic acid induced writhing model in white albino mice (Swiss-webstar strain). The crude extract produced 25.77% inhibition of writhing at the dose of 250 mg/kg body weight & 44.11 % inhibition of writhing at the dose of 500 mg/kg body weight while the standard drug diclofenac inhibition was found to 51.97 % at a dose of 25 mg/kg body weight. The antioxidant property of ethanolic extract of Sida cordifolia was assessed by DPPH (1, 1-diphenyl-2-picryl hydrazyl) free radical scavenging activity. In DPPH scavenging assay the IC50 value was found to be (65 μg/ml) which was comparable to the standard ascorbic acid (16 μg/ml). Phytochemical nature (group determination of plant constituent) and selected phytochemical analysis of the ethanolic extract of the roots of Sida cordifolia indicated the presence of steroid, reducing sugars, tannin & saponin types of compounds. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
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