EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SOME NOVEL DIARYLSULFONYLUREA-CHALCONE HYBRIDS IN CARRAGEENAN???INDUCED PAW EDEMA IN RATS

Bharat Kumar B*, SVGK Kaladhar D, Vasudeva Rao A, Divakar NLS, Subhash Y, Amita CMP

A series of some novel diarylsulfonylurea-chalcone hybrids synthesized in our earlier study as potential 5- lipoxygenase inhibitors were now subjected for the anti-inflammatory activity by using carrageenan induced rat paw edema method. The compounds 4o, 4q, 4r, 4t and 4y were selected for the study; the rationale behind the selection of these compounds is mainly due to their potential inhibitory activity against 5-lipoxygenase enzyme. Among the compounds tested 4r and 4o have been displayed remarkable percentage reduction of paw volume in comparison with standard drug Aceclofenac.