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Abstract

Ethanolic extract of Alangium salvifolium stem bark attenuates gentamicininduced nephrotoxicity in rats

Karra Geetha*, Nadendla Rama rao

Objective: To study the nephroprotective, nephrocurative effect of Alangium salvifolium ethanolic stem bark extract in gentamicin induced nephrotoxicity. Materials and methods: Nephrotoxicity was induced in wistar male rats by intraperitoneal administration of gentamicin at 40mg/kg b.wt /day for 7 days. Alangium salvifolium was selected to check the effect by using ethanolic bark extract with different doses (250,500,750 mg/kg body weight respectively), was given by oral route. Serum parameters (serum creatinine, serum proteins and blood urea nitrogen (BUN)), other parameters like body weight, in vivo antioxidants catalase, Superoxide dismutase (SOD), reduced glutathione (GSH) and Lipid peroxidase level were determined on 22nd day in wistar male rats. Histopathological study of kidney was studied. Results: The three doses of the extracts produced significant nephroprotective, nephrocurative activities with increased doses. The increased actions of nephroprotective, nephrocurative activity in gentamicin induced nephrotoxicity models as evident by decrease in serum creatinine, serum urea, serum proteins, BUN levels and lipid peroxidation (MDA).The increased glutathione (GSH), catalase (CAT) activities when compared to gentamicin control group which was further confirmed by histopathological study. Conclusion: The study revealed that ethanolic bark extract of Alangium salvifolium (EBAS) recovered the nephrotoxicity induced by gentamicin experimental animals.


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